This project focuses on the development of microsystem substrates and the integration of smart materials enabling enhanced surfaces for bioprocesses. The enzymatic cofactor regeneration of NAD to NADH by hydrogenase using in situ generated H2 will be taken as a model reaction. This model reaction will be realised in a microsystem carrier with integrated electrodes and optical waveguides enabling space-resolved biocatalytic reaction sequences with controllable individual steps. Our novel approach of combining 3D manufacturing with microsystems technology will pave the ground for a new generation of adaptive components for future SMART bioreactors.
