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Item type:Publication, Access status: without files , Deep transfer learning methods for colon cancer classification in confocal laser microscopy images(2019-11-01); ; ; ; Purpose: The gold standard for colorectal cancer metastases detection in the peritoneum is histological evaluation of a removed tissue sample. For feedback during interventions, real-time in vivo imaging with confocal laser microscopy has been proposed for differentiation of benign and malignant tissue by manual expert evaluation. Automatic image classification could improve the surgical workflow further by providing immediate feedback. Methods: We analyze the feasibility of classifying tissue from confocal laser microscopy in the colon and peritoneum. For this purpose, we adopt both classical and state-of-the-art convolutional neural networks to directly learn from the images. As the available dataset is small, we investigate several transfer learning strategies including partial freezing variants and full fine-tuning. We address the distinction of different tissue types, as well as benign and malignant tissue. Results: We present a thorough analysis of transfer learning strategies for colorectal cancer with confocal laser microscopy. In the peritoneum, metastases are classified with an AUC of 97.1, and in the colon the primarius is classified with an AUC of 73.1. In general, transfer learning substantially improves performance over training from scratch. We find that the optimal transfer learning strategy differs for models and classification tasks. Conclusions: We demonstrate that convolutional neural networks and transfer learning can be used to identify cancer tissue with confocal laser microscopy. We show that there is no generally optimal transfer learning strategy and model as well as task-specific engineering is required. Given the high performance for the peritoneum, even with a small dataset, application for intraoperative decision support could be feasible.Publicationtype: Journal Article251 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Towards Deep Learning-Based EEG Electrode Detection Using Automatically Generated LabelsElectroencephalography (EEG) allows for source measurement of electrical brain activity. Particularly for inverse localization, the electrode positions on the scalp need to be known. Often, systems such as optical digitizing scanners are used for accurate localization with a stylus. However, the approach is time-consuming as each electrode needs to be scanned manually and the scanning systems are expensive. We propose using an RGBD camera to directly track electrodes in the images using deep learning methods. Studying and evaluating deep learning methods requires large amounts of labeled data. To overcome the time-consuming data annotation, we generate a large number of ground-truth labels using a robotic setup. We demonstrate that deep learning-based electrode detection is feasible with a mean absolute error of 5.69 +- 6.1mm and that our annotation scheme provides a useful environment for studying deep learning methods for electrode detection.Publicationtype: Conference Paper81 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , 4D spatio-temporal deep learning with 4D fMRI data for autism spectrum disorder classification(Information Extraction and Synthesis Laboratory, College of Information and Computer Science, University of Massachusetts Amherst, 2019-07); ; Autism spectrum disorder (ASD) is associated with behavioral and communication problems. Often, functional magnetic resonance imaging (fMRI) is used to detect and characterize brain changes related to the disorder. Recently, machine learning methods have been employed to reveal new patterns by trying to classify ASD from spatio-temporal fMRI images. Typically, these methods have either focused on temporal or spatial information processing. Instead, we propose a 4D spatio-temporal deep learning approach for ASD classification where we jointly learn from spatial and temporal data. We employ 4D convolutional neural networks and convolutional-recurrent models which outperform a previous approach with an F1-score of 0.71 compared to an F1-score of 0.65Publicationtype: Conference Paper204 119