Horse liver alcohol dehydrogenase-datalyzed oxidative lactamization of amino alcohols

Publikationstyp
Journal Article
Date Issued
2018-08-07
Sprache
English
Author(s)
Huang, Lei  
Sayoga, Giovanni  
Hollmann, Frank  
Kara, Selin  
Institut
Technische Biokatalyse V-6  
TORE-URI
http://hdl.handle.net/11420/3054
Journal
ACS catalysis  
Volume
8
Issue
9
Start Page
8680
End Page
8684
Citation
ACS Catalysis 9 (8): 8680-8684 (2018-09-07)
Publisher DOI
10.1021/acscatal.8b02355
Scopus ID
2-s2.0-85052392101
Publisher
ACS
A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.
DDC Class
540: Chemie
600: Technik