Ganzheitliche Analyse dreiphasiger enzymatischer Reaktionssysteme mittels kontinuierlicher Flüssig-Flüssig-Phasentrennung [Holistic analysis of three-phasic enzymatic reaction systems using continuous liquid-liquid phase separation]

Zitzewitz, Philip; Fieg, Georg

Ganzheitliche Analyse dreiphasiger enzymatischer Reaktionssysteme mittels kontinuierlicher Flüssig-Flüssig-Phasentrennung [Holistic analysis of three-phasic enzymatic reaction systems using continuous liquid-liquid phase separation]

Publikationstyp

Journal Article

Publikationsdatum

2015-06-01

Sprache

English

Author

Zitzewitz, Philip

Fieg, Georg

Institut

Prozess- und Anlagentechnik V-4

TORE-URI

http://hdl.handle.net/11420/7334

Enthalten in

Chemie - Ingenieur - Technik

Volume

87

Issue

6

Start Page

746

End Page

755

Citation

Chemie-Ingenieur-Technik 6 (87): 746-755 (2015-06-01)

Publisher DOI

10.1002/cite.201400143

Scopus ID

2-s2.0-84929708881

The enzymatic hydrolysis of methyl octanoate via immobilized Candida antarctica lipase B was studied as an exemplary reference system from the field of enzymatically catalyzed liquid-liquid-solid systems. The experimental investigation of this system was performed in an innovative recycle packed-bed reactor with continuous liquid-liquid phase separation. This setup allows for both a biphasic as well as a singular phase reactor feed. For the first time, a holistic experimental investigation of both operation modes at various operating conditions was conducted. In addition to the presentation of the experimental results, the basics of the mathematical modeling are shown and a model validation is performed.

Schlagworte

Centrifuge

Enzymatic catalysis

Mathematical modeling

Multiphasic reactor

Recycle packed-bed reactor

Options

Ganzheitliche Analyse dreiphasiger enzymatischer Reaktionssysteme mittels kontinuierlicher Flüssig-Flüssig-Phasentrennung [Holistic analysis of three-phasic enzymatic reaction systems using continuous liquid-liquid phase separation]