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Reaction engineering in biocatalytic reactive distillation
Citation Link: https://doi.org/10.15480/882.1919
Publikationstyp
Doctoral Thesis
Date Issued
2018
Sprache
English
Author(s)
Advisor
Referee
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2018-10-12
Institut
TORE-DOI
Reactive distillation is a well-established unit operation in chemical industry incorporating reaction and separation in one device. In this study, practicability of Candida antarctica lipase B is evaluated for biocatalytic kinetic resolution of either secondary alcohols or chiral esters to broaden the scope of feasible reactions in reactive distillation. In fact, successful operation of an integrated batch biocatalytic reactive distillation column is approved by in situ isolation of the chiral target compound (S)-2-pentanol with high purity (x = 0.95 mol/mol) and excellent enantiomeric excess (ee > 99 %). Finally, generated experimental data are used to propose an approach comprising criteria for selection of reaction candidates as well as the definition of an operation window.
Subjects
Reactive Distillation
Enzymes
process development
process window
DDC Class
600: Technik
620: Ingenieurwissenschaften
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181202_Dissertation_STK_final print version.pdf
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4.35 MB
Format
Adobe PDF