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Prozessentwicklung einer linearen Reaktionskaskade zur biotechnologischen Herstellung von epsilon-Caprolacton
Citation Link: https://doi.org/10.15480/882.1914
Publikationstyp
Doctoral Thesis
Date Issued
2018
Sprache
German
Author(s)
Advisor
Referee
Pörtner, Ralf
Title Granting Institution
Technische Universität Hamburg-Harburg
Place of Title Granting Institution
Hamburg
Examination Date
2018-03-27
Institut
TORE-DOI
In this work, the enzymatic synthesis of ε-caprolactone was investigated starting from cyclohexanol and utilising an alcohol dehydrogenase and an oxygen dependent Baeyer-villiger monooxygenase. Additionally, a lipase was deployed for the hydrolysis and polymerisation of ε-caprolactone. As part of the process development, each enzyme and reaction step was characterised to determine a process design with ideal reaction conditions. Therefore, a comparison between reactions in batch and fed-batch mode was conducted. On the basis of a kinetic model, simulations of the reaction sequence were realised to predict experimental data. A membrane aeration was implemented into the process design for oxygen supply.
Subjects
caprolactone
baeyer-villiger monooxygenase
cascade reactions
membrane aeration
DDC Class
620: Ingenieurwissenschaften
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Dissertation_Christian Scherkus_Veröffentlichung.pdf
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5.42 MB
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