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Separation of enantiomers of ibuprofen on chiral stationary phases by packed column supercritical fluid chromatography
Publikationstyp
Journal Article
Date Issued
2001-10-17
Sprache
German
Author(s)
Institut
TORE-URI
Journal
Volume
937
Issue
1-2
Start Page
135
End Page
138
Citation
Journal of Chromatography A 1-2 (937): 135-138 (2001)
Publisher DOI
Scopus ID
Publisher
Elsevier Direct
A packed column supercritical fluid chromatography (SFC) method for the separation of ibuprofen enantiomers on a chiral stationary phase and CO2 with modifier as mobile phase has been developed at an analytical scale. Among 11 different stationary phases the Kromasil CHI-TBB phase showed by far the best separation properties. The influence of different modifiers, injection solvents, temperature, and pressure, and density of the fluid, respectively, on the separation behavior has been studied. It was found that the separation behavior strongly depends on the type of modifier and the modifier content. Temperature and pressure are of less influence.
Subjects
chiral stationary phases, SFC
enantiomer separation
ibuprofen
supercritical fluid chromatography
DDC Class
500: Naturwissenschaften
530: Physik