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Entwicklung eines biokatalytischen Verfahrens zur asymmetrischen Produktion von Alkoholen
Citation Link: https://doi.org/10.15480/882.804
Other Titles
Development of a biocatalytic process for the asymmetric production of alcohols
Publikationstyp
Doctoral Thesis
Date Issued
2010
Sprache
German
Author(s)
Advisor
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2010-04-10
Institut
TORE-DOI
This thesis presents the process development for the biocatalytic reduction of prochiral ketones based on oxidoreductases. Conversion to the corresponding alcohols was catalyzed by an alcohol dehydrogenase ADH-'A' derived from Rhodococcus ruber DSM 44541. Results from the analysis of the thermodynamic equilibrium and the retention of the biocatalyst were successfully integrated into a continuously operated reactor system. Furhtermore, different methods for the non-invasive online-analysis of the reaction mixture composition were investigated.
Subjects
Alkoholdehydrogenase
Biokatalyse
online-Analyse
chirale Alkohole
Immobilisierung
alcohol dehydrogenase
biocatalysis
online-analysis
chiral alcohol
immobilization
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Dissertation_Katja_Goldberg_1.pdf
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