Facilitated proton transfer across liquid | liquid interfaces under forced hydrodynamic conditions. Determination of partition coefficients of neutral weak bases

A novel quantitative methodology to determine the partition coefficients of neutral weak bases is developed. This new electrochemical approach is based on the measurement of the total transferred charge across the oil | water interface under forced hydrodynamic conditions. The complete procedure has been validated by computational simulations and experimental results (Tylosin A). In addition, flow pattern caused inside the electrochemical cell was simulated with computational fluid dynamics using finite element methods and correlated with experimental results obtained by magnetic resonance imaging.

Subjects

Facilitated proton transfer

Finite element method

Forced hydrodynamic conditions

Liquid

liquid interface

Magnetic resonance imaging

Partition coefficient

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Facilitated proton transfer across liquid | liquid interfaces under forced hydrodynamic conditions. Determination of partition coefficients of neutral weak bases