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Überwindung der Limitierungen von L- Threoninaldolasen in der Biokatalyse: durch Reaktionstechnik zu hocheffizienten Anwendungen
Citation Link: https://doi.org/10.15480/882.18003
Publikationstyp
Report
Date Issued
2025-06-30
Sprache
English
TORE-DOI
Citation
Technische Universität Hamburg (2025)
Peer Reviewed
true
Threonine aldolases (LTA) have been demonstrated to be a synthetically valuable enzyme class for performing diastereoselective C-C forming reactions. Such biotransformations are of interest for the preparation of pharmaceuticals and fine chemicals as they catalyze asymmetric aldol reactions with glycine as readily available aldol donor, thus resulting in the formation of α-amino-β-hydroxycarboxylic acids. So far, a major limitation has been the non-favourable diastereoselectivity due to the switch from a kinetic to thermodynamic control of the biocatalytic reaction system. This project aimed for understanding and overcoming such process limitations.
Subjects
Aldolase
enzymes
biotechnology
reaction engineering
process development
DDC Class
572: Biochemistry
660.6: Biotechnology
Publication version
publishedVersion
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26_08_DFG_Abschlussbericht_Threoninaldolasen.pdf
Type
Main Article
Size
511.4 KB
Format
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