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Entwicklung und Erprobung eines membranbasierten Perfusionsbioreaktors für die industrielle Produktion fragiler biopharmazeutischer Wirkstoffe in Zellkulturen
Citation Link: https://doi.org/10.15480/882.1041
Other Titles
Development and testing o a membrane based perfusion bioreactor fort he industrial production of fragile pharmaceutical proteins in cell cultures
Publikationstyp
Doctoral Thesis
Date Issued
2012
Sprache
German
Author(s)
Advisor
Pörtner, Ralf
Title Granting Institution
Technische Universität Hamburg
Place of Title Granting Institution
Hamburg
Examination Date
2011-10-14
Institut
TORE-DOI
A membrane which is pervious for proteins is the heart of the developed single use bioreactor. This allows reliable cell retention and the product (protein) can be harvested in the perfusion flow after a short residence time continuously and cell-free. The function on principle was shown in processes up to 60 days.
Subjects
Bioreaktor
Perfusion
biopharmazeutische Wirkstoffe
Zellkultur
Zellrückhalt
Membran
Bioreactor
perfusion
biopharmaceutical proteins
cell culture
cell retention
membrane
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Dissertation_Rieck_1.pdf
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