Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.4577
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dc.contributor.authorBurek, Bastien Oliver-
dc.contributor.authorDawood, Ayad W. H.-
dc.contributor.authorHollmann, Frank-
dc.contributor.authorLiese, Andreas-
dc.contributor.authorHoltmann, Dirk-
dc.date.accessioned2022-09-05T12:58:18Z-
dc.date.available2022-09-05T12:58:18Z-
dc.date.issued2022-03-21-
dc.identifier.citationFrontiers in Catalysis 2 (): 858706 (2022-03-21)de_DE
dc.identifier.issn2673-7841de_DE
dc.identifier.urihttp://hdl.handle.net/11420/13546-
dc.description.abstractEnzyme catalysis, made tremendous progress over the last years in identification of new enzymes and new enzymatic reactivity’s as well as optimization of existing enzymes. However, the performance of the resulting processes is often still limited, e.g., in regard of productivity, realized product concentrations and the stability of the enzymes. Different topics (like limited specific activity, unfavourable kinetics or limited enzyme stability) can be addressed via enzyme engineering. On the other hand, there is also a long list of topics that are not addressable by enzyme engineering. Here typical examples are unfavourable reaction thermodynamics, selectivity in multistep reactions or low water solubility. These challenges can only be addressed through an adaption of the reaction system. The procedures of process intensification (PI) represent a good approach to reach most suitable systems. The general objective of PI is to achieve significant benefits in terms of capital and operating costs as well as product quality, waste, and process safety by applying innovative principles. The aim of the review is to show the current capabilities and future potentials of PI in enzyme catalysis focused on enzymes of the class of oxidoreductases. The focus of the paper is on alternative methods of energy input, innovative reactor concepts and reaction media with improved properties.-
dc.description.abstractEnzyme catalysis, made tremendous progress over the last years in identification of new enzymes and new enzymatic reactivity’s as well as optimization of existing enzymes. However, the performance of the resulting processes is often still limited, e.g., in regard of productivity, realized product concentrations and the stability of the enzymes. Different topics (like limited specific activity, unfavourable kinetics or limited enzyme stability) can be addressed via enzyme engineering. On the other hand, there is also a long list of topics that are not addressable by enzyme engineering. Here typical examples are unfavourable reaction thermodynamics, selectivity in multistep reactions or low water solubility. These challenges can only be addressed through an adaption of the reaction system. The procedures of process intensification (PI) represent a good approach to reach most suitable systems. The general objective of PI is to achieve significant benefits in terms of capital and operating costs as well as product quality, waste, and process safety by applying innovative principles. The aim of the review is to show the current capabilities and future potentials of PI in enzyme catalysis focused on enzymes of the class of oxidoreductases. The focus of the paper is on alternative methods of energy input, innovative reactor concepts and reaction media with improved properties.en
dc.language.isoende_DE
dc.publisherFrontiers Media S.A.de_DE
dc.relation.ispartofFrontiers in Catalysisde_DE
dc.rightsCC BY 4.0de_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de_DE
dc.subjectbiocatalysisde_DE
dc.subjectprocess intensificationde_DE
dc.subjectenergy input in biocatalysisde_DE
dc.subjectreactor designde_DE
dc.subjectsolventde_DE
dc.subjectelectrobiocatalysisde_DE
dc.subject.ddc600: Technikde_DE
dc.subject.ddc620: Ingenieurwissenschaftende_DE
dc.titleProcess intensification as game changer in enzyme catalysisde_DE
dc.typeArticlede_DE
dc.date.updated2022-09-04T23:03:51Z-
dc.identifier.doi10.15480/882.4577-
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-882.0195922-
tuhh.oai.showtruede_DE
tuhh.abstract.englishEnzyme catalysis, made tremendous progress over the last years in identification of new enzymes and new enzymatic reactivity’s as well as optimization of existing enzymes. However, the performance of the resulting processes is often still limited, e.g., in regard of productivity, realized product concentrations and the stability of the enzymes. Different topics (like limited specific activity, unfavourable kinetics or limited enzyme stability) can be addressed via enzyme engineering. On the other hand, there is also a long list of topics that are not addressable by enzyme engineering. Here typical examples are unfavourable reaction thermodynamics, selectivity in multistep reactions or low water solubility. These challenges can only be addressed through an adaption of the reaction system. The procedures of process intensification (PI) represent a good approach to reach most suitable systems. The general objective of PI is to achieve significant benefits in terms of capital and operating costs as well as product quality, waste, and process safety by applying innovative principles. The aim of the review is to show the current capabilities and future potentials of PI in enzyme catalysis focused on enzymes of the class of oxidoreductases. The focus of the paper is on alternative methods of energy input, innovative reactor concepts and reaction media with improved properties.de_DE
tuhh.publisher.doi10.3389/fctls.2022.858706-
tuhh.publication.instituteTechnische Biokatalyse V-6de_DE
tuhh.identifier.doi10.15480/882.4577-
tuhh.type.opus(wissenschaftlicher) Artikel-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.volume2de_DE
dc.rights.nationallicensefalsede_DE
tuhh.container.articlenumber858706de_DE
local.status.inpressfalsede_DE
local.type.versionpublishedVersionde_DE
datacite.resourceTypeArticle-
datacite.resourceTypeGeneralJournalArticle-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.creatorOrcidBurek, Bastien Oliver-
item.creatorOrcidDawood, Ayad W. H.-
item.creatorOrcidHollmann, Frank-
item.creatorOrcidLiese, Andreas-
item.creatorOrcidHoltmann, Dirk-
item.languageiso639-1en-
item.creatorGNDBurek, Bastien Oliver-
item.creatorGNDDawood, Ayad W. H.-
item.creatorGNDHollmann, Frank-
item.creatorGNDLiese, Andreas-
item.creatorGNDHoltmann, Dirk-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.mappedtypeArticle-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.orcid0000-0003-4821-756X-
crisitem.author.orcid0000-0002-4867-9935-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik (V)-
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