Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.1930
This item is licensed with a CreativeCommons licence by-nc-sa/3.0
DC FieldValueLanguage
dc.contributor.authorHe, Feng-
dc.contributor.authorChen, Hairong-
dc.contributor.authorProbst-Kepper, Michael-
dc.contributor.authorGeffers, Robert-
dc.contributor.authorEifes, Serge-
dc.contributor.authorSol, Antonio del-
dc.contributor.authorSchughart, Klaus-
dc.contributor.authorZeng, An-Ping-
dc.contributor.authorBalling, Rudi-
dc.date.accessioned2018-12-18T11:45:28Z-
dc.date.available2018-12-18T11:45:28Z-
dc.date.issued2012-11-20-
dc.identifier.citationMolecular systems biology (8): art. no. 624 (2012)de_DE
dc.identifier.issn1744-4292de_DE
dc.identifier.urihttp://tubdok.tub.tuhh.de/handle/11420/1933-
dc.description.abstractHuman FOXP3(+)CD25(+)CD4(+) regulatory T cells (Tregs) are essential to the maintenance of immune homeostasis. Several genes are known to be important for murine Tregs, but for human Tregs the genes and underlying molecular networks controlling the suppressor function still largely remain unclear. Here, we describe a strategy to identify the key genes directly from an undirected correlation network which we reconstruct from a very high time-resolution (HTR) transcriptome during the activation of human Tregs/CD4(+) T-effector cells. We show that a predicted top-ranked new key gene PLAU (the plasminogen activator urokinase) is important for the suppressor function of both human and murine Tregs. Further analysis unveils that PLAU is particularly important for memory Tregs and that PLAU mediates Treg suppressor function via STAT5 and ERK signaling pathways. Our study demonstrates the potential for identifying novel key genes for complex dynamic biological processes using a network strategy based on HTR data, and reveals a critical role for PLAU in Treg suppressor function.en
dc.language.isoende_DE
dc.publisherEMBO ; Macmillan Publishersde_DE
dc.relation.ispartofMolecular systems biologyde_DE
dc.rightsCC BY-NC-SA 3.0de_DE
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjecthigh time-resolution time seriesde_DE
dc.subjecthuman CD4 regulatory T cellde_DE
dc.subjectinfer key genes from undirected gene networksde_DE
dc.subjectPlau knockout micede_DE
dc.subjectTreg development and suppressor functionde_DE
dc.subject.ddc570: Biowissenschaften, Biologiede_DE
dc.titlePLAU inferred from a correlation network is critical for suppressor function of regulatory T cellsde_DE
dc.typeArticlede_DE
dc.identifier.urnurn:nbn:de:gbv:830-882.024647-
dc.identifier.doi10.15480/882.1930-
dc.type.diniarticle-
dc.subject.ddccode570-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-882.024647de_DE
tuhh.oai.showtruede_DE
dc.identifier.hdl11420/1933-
tuhh.abstract.englishHuman FOXP3(+)CD25(+)CD4(+) regulatory T cells (Tregs) are essential to the maintenance of immune homeostasis. Several genes are known to be important for murine Tregs, but for human Tregs the genes and underlying molecular networks controlling the suppressor function still largely remain unclear. Here, we describe a strategy to identify the key genes directly from an undirected correlation network which we reconstruct from a very high time-resolution (HTR) transcriptome during the activation of human Tregs/CD4(+) T-effector cells. We show that a predicted top-ranked new key gene PLAU (the plasminogen activator urokinase) is important for the suppressor function of both human and murine Tregs. Further analysis unveils that PLAU is particularly important for memory Tregs and that PLAU mediates Treg suppressor function via STAT5 and ERK signaling pathways. Our study demonstrates the potential for identifying novel key genes for complex dynamic biological processes using a network strategy based on HTR data, and reveals a critical role for PLAU in Treg suppressor function.de_DE
tuhh.publisher.doi10.1038/msb.2012.56-
tuhh.publication.instituteBioprozess- und Biosystemtechnik V-1de_DE
tuhh.identifier.doi10.15480/882.1930-
tuhh.type.opus(wissenschaftlicher) Artikelde
tuhh.institute.germanBioprozess- und Biosystemtechnik V-1de
tuhh.institute.englishBioprozess- und Biosystemtechnik V-1de_DE
tuhh.gvk.hasppnfalse-
openaire.rightsinfo:eu-repo/semantics/openAccessde_DE
dc.type.driverarticle-
dc.rights.ccby-nc-sade_DE
dc.rights.ccversion3.0de_DE
dc.type.casraiJournal Articleen
tuhh.container.volume8de_DE
tuhh.container.startpageArt.-Nr. 624de_DE
dc.rights.nationallicensefalsede_DE
item.fulltextWith Fulltext-
item.creatorOrcidHe, Feng-
item.creatorOrcidChen, Hairong-
item.creatorOrcidProbst-Kepper, Michael-
item.creatorOrcidGeffers, Robert-
item.creatorOrcidEifes, Serge-
item.creatorOrcidSol, Antonio del-
item.creatorOrcidSchughart, Klaus-
item.creatorOrcidZeng, An-Ping-
item.creatorOrcidBalling, Rudi-
item.creatorGNDHe, Feng-
item.creatorGNDChen, Hairong-
item.creatorGNDProbst-Kepper, Michael-
item.creatorGNDGeffers, Robert-
item.creatorGNDEifes, Serge-
item.creatorGNDSol, Antonio del-
item.creatorGNDSchughart, Klaus-
item.creatorGNDZeng, An-Ping-
item.creatorGNDBalling, Rudi-
item.grantfulltextopen-
crisitem.author.deptBioprozess- und Biosystemtechnik V-1-
crisitem.author.orcid0000-0003-2657-7361-
crisitem.author.orcid0000-0002-9926-617X-
crisitem.author.orcid0000-0002-6824-7523-
crisitem.author.orcid0000-0001-9768-7096-
crisitem.author.orcid0000-0003-2902-5650-
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