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Publisher DOI: 10.1002/zamm.201800166
Title: Computational model of gastric motility with active-strain electromechanics
Language: English
Authors: Brandstäter, Sebastian 
Gizzi, Alessio 
Fuchs, Sebastian L. 
Gebauer, Amadeus M. 
Aydin, Roland C. 
Cyron, Christian J. 
Keywords: active-strain electro-mechanics;electrophysiology;finite elasticity;gastric motility
Issue Date: 1-Dec-2018
Publisher: Wiley-VCH
Source: ZAMM Zeitschrift fur Angewandte Mathematik und Mechanik 12 (98): 2177-2197 (2018-12-01)
Journal or Series Name: ZAMM 
Abstract (english): We present an electro-mechanical constitutive framework for the modeling of gastric motility, including pacemaker electrophysiology and smooth muscle contractility. In this framework, we adopt a phenomenological description of the gastric tissue. Tissue electrophysiology is represented by a set of two minimal two-variable models and tissue electromechanics by an active-strain finite elasticity approach. We numerically investigate the implication of the spatial distribution of pacemaker cells on the entrainment and synchronization of the slow waves characterizing gastric motility in health and disease. On simple schematic model geometries, we demonstrate that the proposed computational framework is amenable to large scale in-silico analyses of the complex gastric motility including the underlying electro-mechanical coupling.
DOI: 10.15480/882.1960
ISSN: 1521-4001
Institute: Kontinuums- und Werkstoffmechanik M-15 
Type: (wissenschaftlicher) Artikel
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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