Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.2175
DC FieldValueLanguage
dc.contributor.authorWiedorn, Max Oliver-
dc.contributor.authorOberthür, Dominik-
dc.contributor.authorBean, Richard-
dc.contributor.authorSchubert, Robin-
dc.contributor.authorWerner, Nadine-
dc.contributor.authorAbbey, Brian-
dc.contributor.authorAepfelbacher, Martin-
dc.contributor.authorAdriano, Luigi-
dc.contributor.authorAllahgholi, A.-
dc.contributor.authorAl-Qudami, Nasser-
dc.contributor.authorAndreasson, Jakob-
dc.contributor.authorAplin, Steven-
dc.contributor.authorAwel, Salah-
dc.contributor.authorAyyer, Kartik-
dc.contributor.authorBajt, Saša-
dc.contributor.authorBarák, Imrich-
dc.contributor.authorBari, Sadia-
dc.contributor.authorBielecki, Johan-
dc.contributor.authorBotha, Sabine-
dc.contributor.authorBoukhelef, Djelloul-
dc.contributor.authorBrehm, Wolfgang-
dc.contributor.authorBrockhauser, Sandor-
dc.contributor.authorCheviakov, Igor-
dc.contributor.authorColeman, Matthew A.-
dc.contributor.authorCruz-Mazo, Francisco-
dc.contributor.authorDanilevski, Cyril-
dc.contributor.authorDarmanin, Connie-
dc.contributor.authorDoak, R. Bruce-
dc.contributor.authorDomaracky, Martin-
dc.contributor.authorDörner, Katerina Henrike-
dc.contributor.authorDu, Yang-
dc.contributor.authorFangohr, Hans-
dc.contributor.authorFleckenstein, Holger-
dc.contributor.authorFrank, Matthias-
dc.contributor.authorFromme, Petra-
dc.contributor.authorGañán-Calvo, Alfonso M.-
dc.contributor.authorGevorkov, Yaroslav-
dc.contributor.authorGiewekemeyer, Klaus-
dc.contributor.authorGinn, Helen Mary-
dc.contributor.authorGraafsma, Heinz-
dc.contributor.authorGraceffa, Rita-
dc.contributor.authorGreiffenberg, Dominic-
dc.contributor.authorGumprecht, Lars-
dc.contributor.authorGöttlicher, Peter-
dc.contributor.authorHajdu, János-
dc.contributor.authorHauf, Steffen-
dc.contributor.authorHeymann, Michael-
dc.contributor.authorHolmes, Susannah-
dc.contributor.authorHorke, Daniel A.-
dc.contributor.authorHunter, Mark S.-
dc.contributor.authorImlau, Siegfried-
dc.contributor.authorKaukher, Alexander-
dc.contributor.authorKim, Yoonhee-
dc.contributor.authorKlyuev, Alexander-
dc.contributor.authorKnoška, Juraj-
dc.contributor.authorKobe, Bostjan-
dc.contributor.authorKuhn, Manuela-
dc.contributor.authorKupitz, Christopher-
dc.contributor.authorKüpper, Jochen-
dc.contributor.authorLahey-Rudolph, Janine Mia-
dc.contributor.authorLaurus, Torsten-
dc.contributor.authorLe Cong, Karoline-
dc.contributor.authorLetrun, Romain-
dc.contributor.authorXavier, Paulrajpillai Lourdu-
dc.contributor.authorMaia, Luis-
dc.contributor.authorMaia, Filipe R. N. C.-
dc.contributor.authorMariani, Valerio-
dc.contributor.authorMesserschmidt, Marc-
dc.contributor.authorMetz, Markus-
dc.contributor.authorMezza, Davide-
dc.contributor.authorMichelat, Thomas-
dc.contributor.authorMills, Grant-
dc.contributor.authorMonteiro, Diana C.F.-
dc.contributor.authorMorgan, Andrew J.-
dc.contributor.authorMühlig, Kerstin-
dc.contributor.authorMunke, Anna-
dc.contributor.authorMünnich, Astrid-
dc.contributor.authorNette, Julia-
dc.contributor.authorNugent, Keith A.-
dc.contributor.authorNuguid, Theresa-
dc.contributor.authorOrville, Allen M.-
dc.contributor.authorPandey, Suraj-
dc.contributor.authorPena, Gisel-
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dc.contributor.authorPöhlsen, Jennifer-
dc.contributor.authorPrevitali, Gianpietro-
dc.contributor.authorRedecke, Lars-
dc.contributor.authorRiekehr, Winnie Maria-
dc.contributor.authorRohde, Holger-
dc.contributor.authorRound, Adam-
dc.contributor.authorSafenreiter, Tatiana-
dc.contributor.authorSarrou, Iosifina-
dc.contributor.authorSato, Tokushi-
dc.contributor.authorSchmidt, Marius-
dc.contributor.authorSchmitt, Bernd-
dc.contributor.authorSchönherr, Robert-
dc.contributor.authorSchulz, Joachim-
dc.contributor.authorSellberg, Jonas Alexander-
dc.contributor.authorSeibert, M. Marvin-
dc.contributor.authorSeuring, Carolin-
dc.contributor.authorShelby, Megan L.-
dc.contributor.authorShoemann, Robert L.-
dc.contributor.authorSikorski, Marcin-
dc.contributor.authorSilenzi, Alessandro-
dc.contributor.authorStan, Claudiu A.-
dc.contributor.authorShi, Xintian-
dc.contributor.authorStern, Stephan-
dc.contributor.authorSztuk-Dambietz, Jolanta-
dc.contributor.authorSzuba, Janusz-
dc.contributor.authorTolstikova, Aleksandra-
dc.contributor.authorTrebbin, Martin-
dc.contributor.authorTrunk, Ulrich-
dc.contributor.authorVagovic, Patrik-
dc.contributor.authorVe, Thomas-
dc.contributor.authorWeinhausen, Britta-
dc.contributor.authorWhite, Thomas A.-
dc.contributor.authorWrona, Krzysztof-
dc.contributor.authorXu, C.-
dc.contributor.authorYefanov, Oleksandr-
dc.contributor.authorZatsepin, Nadia-
dc.contributor.authorZhang, Jiaguo-
dc.contributor.authorPerbandt, Markus-
dc.contributor.authorMancuso, Adrian P.-
dc.contributor.authorBetzel, Christian-
dc.contributor.authorChapman, Henry N.-
dc.contributor.authorBanty, Anton-
dc.date.accessioned2019-05-03T06:51:31Z-
dc.date.available2019-05-03T06:51:31Z-
dc.date.issued2018-10-02-
dc.identifier.citationNature Communications 1 (9): 4025 - (2018-10-02)de_DE
dc.identifier.issn2041-1723de_DE
dc.identifier.urihttp://hdl.handle.net/11420/2300-
dc.description.abstractThe new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.en
dc.language.isoende_DE
dc.publisherNature Publishing Group UKde_DE
dc.relation.ispartofNature Communicationsde_DE
dc.rightsinfo:eu-repo/semantics/openAccessde_DE
dc.subject.ddc600: Technikde_DE
dc.titleMegahertz serial crystallographyde_DE
dc.typeArticlede_DE
dc.identifier.urnurn:nbn:de:gbv:830-882.030425-
dc.identifier.doi10.15480/882.2175-
dc.type.diniarticle-
dc.subject.ddccode600-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-882.030425-
tuhh.oai.showtruede_DE
tuhh.abstract.englishThe new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.de_DE
tuhh.publisher.doi10.1038/s41467-018-06156-7-
tuhh.publication.instituteBildverarbeitungssysteme E-2de_DE
tuhh.identifier.doi10.15480/882.2175-
tuhh.type.opus(wissenschaftlicher) Artikel-
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tuhh.institute.englishBildverarbeitungssysteme E-2de_DE
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openaire.rightsinfo:eu-repo/semantics/openAccessde_DE
dc.type.driverarticle-
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/de_DE
dc.type.casraiJournal Article-
tuhh.container.issue1de_DE
tuhh.container.volume9de_DE
tuhh.container.startpageArt..-Nr. 4025de_DE
dc.rights.nationallicensefalsede_DE
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