Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.2296
DC FieldValueLanguage
dc.contributor.authorTaheri, Shahed-
dc.contributor.authorWinkler, Thomas-
dc.contributor.authorSchenk, Lia Sabrina-
dc.contributor.authorNeuerburg, Carl-
dc.contributor.authorBaumbach, Sebastian Felix-
dc.contributor.authorZustin, Jozef-
dc.contributor.authorLehmann, Wolfgang-
dc.contributor.authorSchilling, Arndt Friedrich-
dc.date.accessioned2019-06-26T11:22:09Z-
dc.date.available2019-06-26T11:22:09Z-
dc.date.issued2019-02-12-
dc.identifier.citationInternational Journal of Molecular Sciences 3 (20): 770 (2019)de_DE
dc.identifier.issn1422-0067de_DE
dc.identifier.urihttp://hdl.handle.net/11420/2818-
dc.description.abstractIt is widely accepted that the subchondral bone (SCB) plays a crucial role in the physiopathology of osteoarthritis (OA), although its contribution is still debated. Much of the pre-clinical research on the role of SCB is concentrated on comparative evaluations of healthy vs. early OA or early OA vs. advanced OA cases, while neglecting how pure maturation could change the SCB’s microstructure. To assess the transformations of the healthy SCB from young age to early adulthood, we examined the microstructure and material composition of the medial condyle of the femur in calves (three months) and cattle (18 months) for the calcified cartilage (CC) and the subchondral bone plate (SCBP). The entire subchondral zone (SCZ) was significantly thicker in cattle compared to calves, although the proportion of the CC and SCBP thicknesses were relatively constant. The trabecular number (Tb.N.) and the connectivity density (Conn.D) were significantly higher in the deeper region of the SCZ, while the bone volume fraction (BV/TV), and the degree of anisotropy (DA) were more affected by age rather than the region. The mineralization increased within the first 250 µm of the SCZ irrespective of sample type, and became stable thereafter. Cattle exhibited higher mineralization than calves at all depths, with a mean Ca/P ratio of 1.59 and 1.64 for calves and cattle, respectively. Collectively, these results indicate that the SCZ is highly dynamic at early age, and CC is the most dynamic layer of the SCZ.en
dc.description.sponsorshipGerman Research Society (Deutsche Forschungsgemeinschaft, DFG) to Arndt F Schilling (SCH 857/9-1)de_DE
dc.language.isoende_DE
dc.relation.ispartofInternational journal of molecular sciencesde_DE
dc.rightsCC BY 4.0de_DE
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectbone histomorphometryde_DE
dc.subjectsubchondral bonede_DE
dc.subjectmicrocomputed tomographyde_DE
dc.subjectosteoarthritisde_DE
dc.subject.ddc610: Medizinde_DE
dc.titleDevelopmental transformation and reduction of connective cavities within the subchondral bonede_DE
dc.typeArticlede_DE
dc.identifier.urnurn:nbn:de:gbv:830-882.036755-
dc.identifier.doi10.15480/882.2296-
dc.type.diniarticle-
dc.subject.ddccode610-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-882.036755-
tuhh.oai.showtruede_DE
tuhh.abstract.englishIt is widely accepted that the subchondral bone (SCB) plays a crucial role in the physiopathology of osteoarthritis (OA), although its contribution is still debated. Much of the pre-clinical research on the role of SCB is concentrated on comparative evaluations of healthy vs. early OA or early OA vs. advanced OA cases, while neglecting how pure maturation could change the SCB’s microstructure. To assess the transformations of the healthy SCB from young age to early adulthood, we examined the microstructure and material composition of the medial condyle of the femur in calves (three months) and cattle (18 months) for the calcified cartilage (CC) and the subchondral bone plate (SCBP). The entire subchondral zone (SCZ) was significantly thicker in cattle compared to calves, although the proportion of the CC and SCBP thicknesses were relatively constant. The trabecular number (Tb.N.) and the connectivity density (Conn.D) were significantly higher in the deeper region of the SCZ, while the bone volume fraction (BV/TV), and the degree of anisotropy (DA) were more affected by age rather than the region. The mineralization increased within the first 250 µm of the SCZ irrespective of sample type, and became stable thereafter. Cattle exhibited higher mineralization than calves at all depths, with a mean Ca/P ratio of 1.59 and 1.64 for calves and cattle, respectively. Collectively, these results indicate that the SCZ is highly dynamic at early age, and CC is the most dynamic layer of the SCZ.de_DE
tuhh.publisher.doi10.3390/ijms20030770-
tuhh.publication.instituteBiomechanik M-3de_DE
tuhh.identifier.doi10.15480/882.2296-
tuhh.type.opus(wissenschaftlicher) Artikel-
tuhh.institute.germanBiomechanik M-3de
tuhh.institute.englishBiomechanik M-3de_DE
tuhh.gvk.hasppnfalse-
openaire.rightsinfo:eu-repo/semantics/openAccessde_DE
dc.type.driverarticle-
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/de_DE
dc.type.casraiJournal Article-
tuhh.container.issue3de_DE
tuhh.container.volume20de_DE
tuhh.container.startpageArtikel Nr. 770de_DE
dc.rights.nationallicensefalsede_DE
item.creatorOrcidTaheri, Shahed-
item.creatorOrcidWinkler, Thomas-
item.creatorOrcidSchenk, Lia Sabrina-
item.creatorOrcidNeuerburg, Carl-
item.creatorOrcidBaumbach, Sebastian Felix-
item.creatorOrcidZustin, Jozef-
item.creatorOrcidLehmann, Wolfgang-
item.creatorOrcidSchilling, Arndt Friedrich-
item.fulltextWith Fulltext-
item.creatorGNDTaheri, Shahed-
item.creatorGNDWinkler, Thomas-
item.creatorGNDSchenk, Lia Sabrina-
item.creatorGNDNeuerburg, Carl-
item.creatorGNDBaumbach, Sebastian Felix-
item.creatorGNDZustin, Jozef-
item.creatorGNDLehmann, Wolfgang-
item.creatorGNDSchilling, Arndt Friedrich-
item.grantfulltextopen-
item.languageiso639-1other-
crisitem.author.deptBiomechanik M-3-
crisitem.author.deptBiomechanik M-3-
crisitem.author.parentorgStudiendekanat Maschinenbau-
crisitem.author.parentorgStudiendekanat Maschinenbau-
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