Publisher DOI: 10.1021/acscatal.8b02355
Title: Horse liver alcohol dehydrogenase-datalyzed oxidative lactamization of amino alcohols
Language: English
Authors: Huang, Lei 
Sayoga, Giovanni Vallian 
Hollmann, Frank 
Kara, Selin 
Issue Date: 7-Aug-2018
Publisher: ACS
Source: ACS Catalysis 9 (8): 8680-8684 (2018-09-07)
Journal or Series Name: ACS catalysis 
Abstract (english): A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.
ISSN: 2155-5435
Institute: Technische Biokatalyse V-6 
Type: (wissenschaftlicher) Artikel
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