Publisher DOI: 10.1016/j.cej.2016.11.127
Title: Pilot-scale validation of enzymatic reactive distillation for butyl butyrate production
Language: English
Authors: Wierschem, Matthias 
Schlimper, Stefan 
Heils, Rene 
Smirnova, Irina 
Kiss, Anton Alexandru 
Skiborowski, Mirko 
Lutze, Philip 
Keywords: Biocatalysis;Hydrodynamics;Lipase;Modeling;Process intensification;Reactive distillation
Issue Date: 16-Nov-2016
Publisher: Elsevier
Source: Chemical Engineering Journal (312): 106-117 (2017)
Journal or Series Name: Chemical engineering journal 
Abstract (english): For enzyme-catalyzed reactions, batch processes using stirred tank reactors are the state-of-the-art production mode. The yield of the process may be limited by reaction equilibrium, product inhibition of the enzyme, low concentrations and possibly low reaction rates, while the recovery of the product may be limited due to thermodynamic constraints such as azeotropes. Using enzymes in an integrated reactive distillation process can overcome these limitations and provides a cost advantage over classic batch reactor processes. The aim of this paper is i) to report the successful pilot-scale experimental validation of an Enzymatic Reactive Distillation (ERD) process for the synthesis of butyl butyrate and ii) to establish a rate-based model for conceptual process design which can be quickly adapted to other systems. The main novelty is the application of a continuous RD column with enzymes as a heterogeneous catalyst provided in two different types of catalytic packing: loosely filled immobilized enzyme beads in standard packings with catalyst pockets and gauze packings with catalytic coating. Experimental pilot-scale experiments show the feasibility of ERD and allow the comparison of the different packing types based on catalytic performance as well as stability. Furthermore, these experiments are used to validate a predictive rate-based model to describe ERD which can be used to check the sensitivity of process and design parameters as well as to provide a quick adaption to other systems for quick evaluation.
ISSN: 0375-8699
Institute: Thermische Verfahrenstechnik V-8 
Type: (wissenschaftlicher) Artikel
Funded by: Funding from the Ministry of Innovation, Science and Research of North Rhine-Westphalia in the framework of CLIB-Graduate Cluster Industrial Biotechnology, contract no: 314 – 108 001 08 and the European Community‘s Seventh Framework Programme under grant agreement no. FP7-NMP-2012-309874.
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