Electrical Impedance Spectroscopy for Characterization of Prostate PC-3 and du 145 Cancer Cells

Abstract

The impedance profile of the human PC-3 and DU 145 prostate cancer cells were recorded and compared using Electrical Impedance Spectroscopy. Cells were measured in a special chamber using a four terminal setup to avoid parasitic effects of electrode polarization in low frequencies. Our results show that the two cancer cell lines are readily distinguishable by their impedance spectrum. As PC-3 cells have been shown to be spontaneously metastatic in previous xenograft experiments while DU 145 cells were non-metastatic, Electrical Impedance Spectroscopy has the potential to be developed into a simple diagnostic tool to distinguish metastatic from non-metastatic cells.