Publisher DOI: 10.1016/j.supflu.2007.02.011
Title: Management and control of modifier content in preparative SFC solvent cycles
Language: English
Authors: Kaemmerer, Henning 
Brunner, Gerd 
Johannsen, Monika  
Keywords: Control;Fourier transform infrared spectroscopy (FTIR);Modifier;Simulated moving bed (SMB);Solvent cycle;Supercritical fluid chromatography (SFC)
Issue Date: 2007
Source: Journal of Supercritical Fluids 2 (43): 204-213 (2007)
Journal or Series Name: The journal of supercritical fluids 
Abstract (english): The objective of this work was to establish a solvent cycle with a possibility for modifier control in a preparative supercritical fluid chromatography simulated moving bed plant (SFC-SMB). Fourier transform infrared (FTIR) spectroscopy and flame ionization detection (FID) have been investigated for measuring alcohol concentrations in supercritical carbon dioxide. The integration of these in-line techniques into a modifier control schema allowed the operation of a closed loop SFC-SMB cycle. The applicability of the developed control concept for usage of 2-propanol in supercritical carbon dioxide has been verified by an experimental test series involving an eight column SFC-SMB plant. Different process variations have been compared in terms of energy and solvent consumption. Hereby, savings of almost all CO2 and 76% modifier could be achieved.
ISSN: 0896-8446
Institute: Thermische Verfahrenstechnik V-8 
Type: (wissenschaftlicher) Artikel
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