DC FieldValueLanguage
dc.contributor.authorAntonelli, Antonella-
dc.contributor.authorSzwargulski, Patryk-
dc.contributor.authorScarpa, Emanuele Salvatore-
dc.contributor.authorThieben, Florian-
dc.contributor.authorGruettner, Cordula-
dc.contributor.authorAmbrosi, Gianluca-
dc.contributor.authorGuidi, Loretta-
dc.contributor.authorLudewig, Peter-
dc.contributor.authorKnopp, Tobias-
dc.contributor.authorMagnani, Mauro-
dc.date.accessioned2020-04-17T11:49:19Z-
dc.date.available2020-04-17T11:49:19Z-
dc.date.issued2020-04-01-
dc.identifier.citationNanomedicine 8 (15): 739-753 (2020-04-01)de_DE
dc.identifier.issn1748-6963de_DE
dc.identifier.urihttp://hdl.handle.net/11420/5768-
dc.description.abstractAim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.en
dc.language.isoende_DE
dc.relation.ispartofNanomedicinede_DE
dc.subjectintravascular contrast agentsde_DE
dc.subjectMPS/MPIde_DE
dc.subjectNMRde_DE
dc.subjectRBCsde_DE
dc.subjectSPIO-loaded RBCsde_DE
dc.subjectTEMde_DE
dc.titleDevelopment of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytesde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.abstract.englishAim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.de_DE
tuhh.publisher.doi10.2217/nnm-2019-0449-
tuhh.publication.instituteBiomedizinische Bildgebung E-5de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.issue8de_DE
tuhh.container.volume15de_DE
tuhh.container.startpage739de_DE
tuhh.container.endpage753de_DE
dc.identifier.scopus2-s2.0-85083002904-
item.creatorOrcidAntonelli, Antonella-
item.creatorOrcidSzwargulski, Patryk-
item.creatorOrcidScarpa, Emanuele Salvatore-
item.creatorOrcidThieben, Florian-
item.creatorOrcidGruettner, Cordula-
item.creatorOrcidAmbrosi, Gianluca-
item.creatorOrcidGuidi, Loretta-
item.creatorOrcidLudewig, Peter-
item.creatorOrcidKnopp, Tobias-
item.creatorOrcidMagnani, Mauro-
item.languageiso639-1en-
item.creatorGNDAntonelli, Antonella-
item.creatorGNDSzwargulski, Patryk-
item.creatorGNDScarpa, Emanuele Salvatore-
item.creatorGNDThieben, Florian-
item.creatorGNDGruettner, Cordula-
item.creatorGNDAmbrosi, Gianluca-
item.creatorGNDGuidi, Loretta-
item.creatorGNDLudewig, Peter-
item.creatorGNDKnopp, Tobias-
item.creatorGNDMagnani, Mauro-
item.openairetypeArticle-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.mappedtypeArticle-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.orcid0000-0003-2563-9006-
crisitem.author.orcid0000-0002-2890-5288-
crisitem.author.orcid0000-0001-9025-6402-
crisitem.author.orcid0000-0002-1589-8517-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
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