DC FieldValueLanguage
dc.contributor.authorSzwargulski, Patryk-
dc.contributor.authorWilmes, Maximilian-
dc.contributor.authorJavidi, Ehsan-
dc.contributor.authorThieben, Florian-
dc.contributor.authorGräser, Matthias-
dc.contributor.authorMartin Koch-
dc.contributor.authorGruettner, Cordula-
dc.contributor.authorAdam, Gerhard-
dc.contributor.authorGerloff, Christian-
dc.contributor.authorMagnus, Tim-
dc.contributor.authorKnopp, Tobias-
dc.contributor.authorLudewig, Peter-
dc.date.accessioned2020-11-09T08:40:21Z-
dc.date.available2020-11-09T08:40:21Z-
dc.date.issued2020-10-27-
dc.identifier.citationACS Nano 10 (14): 13913-13923 (2020-10-27)de_DE
dc.identifier.issn1936-0851de_DE
dc.identifier.urihttp://hdl.handle.net/11420/7791-
dc.description.abstractMagnetic particle imaging (MPI) is an innovative radiation-free tomographic imaging method providing excellent temporal resolution, contrast, sensitivity, and safety. Mobile human MPI prototypes suitable for continuous bedside monitoring of whole-brain perfusion have been developed. However, for the clinical translation of MPI, a crucial gap in knowledge still remains: while MPI can visualize the reduction in blood flow and tissue perfusion in cerebral ischemia, it is unclear whether MPI works in intracranial hemorrhage. Our objective was to investigate the capability of MPI to detect intracranial hemorrhage in a murine model. Intracranial hemorrhage was induced through the injection of collagenase into the striatum of C57BL/6 mice. After the intravenous infusion of a long-circulating MPI-tailored tracer consisting of superparamagnetic iron oxides, we detected the intracranial hemorrhage in less than 3 min and could monitor hematoma expansion in real time. Multicontrast MPI can distinguish tracers based on their physical characteristics, core size, temperature, and viscosity. By employing in vivo multicontrast MPI, we were able to differentiate areas of liquid and coagulated blood within the hematoma, which could provide valuable information in surgical decision making. Multicontrast MPI also enabled simultaneous imaging of hemorrhage and cerebral perfusion, which is essential in the care of critically ill patients with increased intracranial pressure. We conclude that MPI can be used for real-time diagnosis of intracranial hemorrhage. This work is an essential step toward achieving the clinical translation of MPI for point-of-care monitoring of different stroke subtypes.en
dc.language.isoende_DE
dc.relation.ispartofACS nanode_DE
dc.titleMonitoring Intracranial Cerebral Hemorrhage Using Multicontrast Real-Time Magnetic Particle Imagingde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.abstract.englishMagnetic particle imaging (MPI) is an innovative radiation-free tomographic imaging method providing excellent temporal resolution, contrast, sensitivity, and safety. Mobile human MPI prototypes suitable for continuous bedside monitoring of whole-brain perfusion have been developed. However, for the clinical translation of MPI, a crucial gap in knowledge still remains: while MPI can visualize the reduction in blood flow and tissue perfusion in cerebral ischemia, it is unclear whether MPI works in intracranial hemorrhage. Our objective was to investigate the capability of MPI to detect intracranial hemorrhage in a murine model. Intracranial hemorrhage was induced through the injection of collagenase into the striatum of C57BL/6 mice. After the intravenous infusion of a long-circulating MPI-tailored tracer consisting of superparamagnetic iron oxides, we detected the intracranial hemorrhage in less than 3 min and could monitor hematoma expansion in real time. Multicontrast MPI can distinguish tracers based on their physical characteristics, core size, temperature, and viscosity. By employing in vivo multicontrast MPI, we were able to differentiate areas of liquid and coagulated blood within the hematoma, which could provide valuable information in surgical decision making. Multicontrast MPI also enabled simultaneous imaging of hemorrhage and cerebral perfusion, which is essential in the care of critically ill patients with increased intracranial pressure. We conclude that MPI can be used for real-time diagnosis of intracranial hemorrhage. This work is an essential step toward achieving the clinical translation of MPI for point-of-care monitoring of different stroke subtypes.de_DE
tuhh.publisher.doi10.1021/acsnano.0c06326-
tuhh.publication.instituteBiomedizinische Bildgebung E-5de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.issue10de_DE
tuhh.container.volume14de_DE
tuhh.container.startpage13913de_DE
tuhh.container.endpage13923de_DE
dc.identifier.scopus2-s2.0-85094983222de_DE
item.creatorOrcidSzwargulski, Patryk-
item.creatorOrcidWilmes, Maximilian-
item.creatorOrcidJavidi, Ehsan-
item.creatorOrcidThieben, Florian-
item.creatorOrcidGräser, Matthias-
item.creatorOrcidMartin Koch-
item.creatorOrcidGruettner, Cordula-
item.creatorOrcidAdam, Gerhard-
item.creatorOrcidGerloff, Christian-
item.creatorOrcidMagnus, Tim-
item.creatorOrcidKnopp, Tobias-
item.creatorOrcidLudewig, Peter-
item.languageiso639-1en-
item.creatorGNDSzwargulski, Patryk-
item.creatorGNDWilmes, Maximilian-
item.creatorGNDJavidi, Ehsan-
item.creatorGNDThieben, Florian-
item.creatorGNDGräser, Matthias-
item.creatorGNDMartin Koch-
item.creatorGNDGruettner, Cordula-
item.creatorGNDAdam, Gerhard-
item.creatorGNDGerloff, Christian-
item.creatorGNDMagnus, Tim-
item.creatorGNDKnopp, Tobias-
item.creatorGNDLudewig, Peter-
item.openairetypeArticle-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.mappedtypeArticle-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.orcid0000-0003-2563-9006-
crisitem.author.orcid0000-0002-2890-5288-
crisitem.author.orcid0000-0003-1472-5988-
crisitem.author.orcid0000-0002-6484-8882-
crisitem.author.orcid0000-0002-1589-8517-
crisitem.author.orcid0000-0001-9025-6402-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
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