Bletsos, GeorgiosGeorgiosBletsosRung, ThomasThomasRungRadtke, LarsLarsRadtke2024-05-292024-05-292024Computer Methods in Biomechanics and Biomedical Engineering (in Press): (2024)https://hdl.handle.net/11420/47635This article investigates the effect of the cuff size of arterial bypass grafts and the flow conditions on the hemodynamics in the anastomosis (connection) to the artery, using numerical simulations. We consider a fluid-structure interaction problem which is solved based on a partitioned scheme. Additionally, we employ computational fluid dynamics to investigate the effect of a rigid wall assumption. The work focuses on clinically relevant hemodynamic quantities associated with the development of intimal hyperplasia. We also include a model for the prediction of hemolysis into the simulation. The results show that even minor changes of the cuff size can result into significant differences in the corresponding quantities of interest. The importance of the inflow path is shown to be lower than that of the cuff size. The usually employed rigid wall assumption is found to be adequate to address wall shear stress oscillations but falls short on predicting maximum and minimum wall shear stress-related quantities of interest.en1025-58422024bypass-graftfluid–structure interactionHemodynamicshemolysisoscillatory shear indexJournal Article10.1080/10255842.2024.2310747Journal Article