Zustin, JozefJozefZustinSauter, GuidoGuidoSauterAmling, MichaelMichaelAmlingKrause, MatthiasMatthiasKrauseBreer, StefanStefanBreerHahn, MichaelMichaelHahnMorlock, MichaelMichaelMorlockRüther, WolfgangWolfgangRüther2024-03-152024-03-152009-05-01Virchows Archiv 454 (5): 581–588 (2009)https://hdl.handle.net/11420/46540To identify a possible role of lymphocytic infiltrates in failure mechanism of the metal-on-metal hip resurfacing arthroplasty, the extent of lymphocytic infiltration was compared with reasons for prosthesis failure in a series of retrieval specimens. One hundred eighty-one femoral head and neck remnants were subjected to thorough analysis of histological findings and clinical data. Lymphocytic infiltrates were considered weak to moderate in 52 (28.7%) and excessive in ten (5.5%) cases. Six cases with excessive lymphocytic infiltrates belonged to the group of 33 (18.2%) revisions without obvious cause (periprosthetic fracture, component loosening, and infection) for prosthesis failure. Excessive lymphocytic infiltrates were strongly linked to the presence of proliferative desquamative synovitis (p∈<∈0.0001). Both the excessive lymphocytic infiltrates and proliferative desquamative synovitis were associated with female gender (p∈<∈0.05). We hypothesize that a specific cause of groin pain might be related to excessive intraosseous lymphocytic infiltrates and explained possibly by the hypersensitivity reaction of the delayed type after the hip resurfacing arthroplasty. Proliferative desquamative synovitis might constitute another morphologic feature associated with the delayed type hypersensitivity reaction. © 2009 Springer-Verlag.en1432-230720095581588SpringerArthroplasty failureGroin painHip resurfacingHypersensitivityMetal-on-metalT lymphocyteMedicine, HealthEngineeringJournal Article10.1007/s00428-009-0745-7Journal Article