Kampe, PhilippPhilippKampeHerrmann, NickNickHerrmannRuhmlieb, CharlotteCharlotteRuhmliebFinsel, MaikMaikFinselKorup, OliverOliverKorupHorn, RaimundRaimundHornAlbert, JakobJakobAlbert2024-06-272024-06-272024-06-07ACS Sustainable Chemistry & Engineering 12 (25): 9541-9549 (2024-06-07)https://hdl.handle.net/11420/48074The compact profile reactor (CPR) design allows for the simultaneous acquisition of species, temperature, and spatially resolved reaction profiles during high-pressure CO2 hydrogenation to methanol. Indium-based catalysts for CO2 hydrogenation have attracted significant scientific interest since they are more selective, efficient, and resistant to deactivation compared to the state-of-the-art copper-based catalyst. In this study, the reaction profile of In2O3/ZrO2 catalysts is compared to that of the state-of-the-art Cu/ZnO/Al2O3 (CZA) catalyst in a high-pressure CPR. It is demonstrated that the addition of nickel as a promoter significantly enhanced the catalytic activity of pure In2O3/ZrO2. The characterization by H2 TPR and CO2 TPD revealed an increased capacity for both hydrogen and CO2. A detailed comparison and optimization of reaction conditions using Ni–In2O3/ZrO2 as a catalyst are presented. In an optimized experiment, Ni–In2O3/ZrO2 produces 4.90 gMeOH gIn+Ni–1 h–1 at 275 °C, 50 bar, and 63,000 h–1with a methanol selectivity of 73%. Furthermore, no catalyst deactivation caused by metal leaching or sintering could be observed over 90 h time on stream.en2168-048520242595419549American Chemical Societyhttps://creativecommons.org/licenses/by/4.0/methanol synthesiscompact profile reactorCO2 hydrogenationindium oxide catalystNi dopinghydrogen spilloverTechnology::660: Chemical EngineeringJournal Article2024-06-2610.15480/882.1309610.1021/acssuschemeng.4c0327910.15480/882.13096Journal Article