Kaul, MichaelMichaelKaulWeber, Oliver M.Oliver M.WeberHeinen, U.U.HeinenReitmeier, AlineAlineReitmeierMummert, TobiasTobiasMummertJung, CarolineCarolineJungRaabe, NinaNinaRaabeKnopp, TobiasTobiasKnoppIttrich, HaraldHaraldIttrichAdam, GerhardGerhardAdam2019-10-022019-10-022015-05-01RoFo 5 (187): 347-352 (2015-05-01)http://hdl.handle.net/11420/3502Purpose: Magnetic particle imaging (MPI) is a new radiologic imaging modality. For the first time, a commercial preclinical scanner is installed. The goal of this study was to establish a workflow between MPI and magnetic resonance imaging (MRI) scanners for a complete in vivo examination of a mouse and to generate the first co-registered in vivo MR-MP images. Materials and Methods: The in vivo examination of five mice were performed on a preclinical MPI scanner and a 7 Tesla preclinical MRI system. MRI measurements were used for anatomical referencing and validation of the injection of superparamagnetic iron oxide (SPIO) particles during a dynamic MPI scan. We extracted MPI data of the injection phase and co-registered it with MRI data. Results: A workflow process for a combined in vivo MRI and MPI examination was established. A successful injection of ferucarbotran was proven in MPI and MRI. MR-MPI co-registration allocated the SPIOs in the inferior vena cava and the heart during and shortly after the injection. Conclusion: The acquisition of preclinical MPI and MRI data is feasible and allows the combined analysis of MR-MPI information.en0340-161820155347352co-registrationmagnetic particle imagingMR imagingpreclinicalsuperparamagnetic iron oxideworkflowJournal Article10.1055/s-0034-1399344Other