Boberg, MarijaMarijaBobergKnopp, TobiasTobiasKnopp2022-05-102022-05-102022-03-21International Journal on Magnetic Particle Imaging 8 (1, Suppl 1): 2203044 (2022)http://hdl.handle.net/11420/12572Magnetic particle imaging is capable of determining very small concentrations of particles if only a single concentra-tion is present in the field-of-view. Meanwhile the determination of particles with widely differing concentrations is still challenging. In a recent work, we introduced a two-step reconstruction method that tackles this problem by isolating the signal of the lower concentrated tracer for a separate reconstruction. In this work, we adapt the two-step reconstruction method in order to apply a joint reconstruction to the entire signal of all particle concentrations. This is achieved by spatially adaptive Tikhonov regularization.en2365-903320221, Suppl 1Infinite Science Publishinghttps://creativecommons.org/licenses/by/4.0/InformatikMedizinJournal Article10.15480/882.440410.18416/ijmpi.2022.220304410.15480/882.4404Other