Lu, YongtaoYongtaoLuZhu, YifanYifanZhuKrause, MatthiasMatthiasKrauseHuber, GerdGerdHuberLi, JunyanJunyanLi2019-07-172019-07-172019-07Medical Engineering and Physics (69): 43-49 (2019-07)http://hdl.handle.net/11420/2961Prediction of the vertebral failure load is of great importance for the prevention and early treatment of bone fracture. However, an efficient and effective method for accurately predicting the failure load of vertebral bones is still lacking. The aim of the present study was to evaluate the capability of the simulated dual energy X-ray absorptiometry (DXA)-based finite element (FE) model for predicting vertebral failure loads. Thirteen dissected spinal segments (T11/T12/L1) were scanned using a HR-pQCT scanner and then were mechanically tested until failure. The subject-specific three-dimensional (3D) and two-dimensional (2D) FE models of T12 were generated from the HR-pQCT scanner and the simulated DXA images, respectively. Additionally, the areal bone mineral density (aBMD) and areal bone mineral content (aBMC) of T12 were calculated. The failure loads predicted by the simulated DXA-based 2D FE models were more moderately correlated with the experimental failure loads (R2 = 0.66) than the aBMC (R2 = 0.61) and aBMD (R2 = 0.56). The 2D FE models were slightly outperformed by the HR-pQCT-based 3D FE models (R2 = 0.71). The present study demonstrated that the simulated DXA-based 2D FE model has better capability for predicting the vertebral failure loads than the densitometric measurements but is outperformed by the 3D FE model. The 2D FE model is more suitable for clinical use due to the low radiation dose and low cost, but it remains to be validated by further in vitro and in vivo studies.en1350-453320194349Journal Article10.1016/j.medengphy.2019.05.007Other