Doan, Dieu ThiDieu ThiDoanHoang, Manh DatManh DatHoangHeins, Anna-LenaAnna-LenaHeinsKremling, AndreasAndreasKremling2023-08-082023-08-082022-03-08Frontiers in Molecular Biosciences 9: 1-14 (2022-03-08)https://hdl.handle.net/11420/42577Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism.en2296-889X2022114https://creativecommons.org/licenses/by/4.0/kinetic modelmathematical modelingmetabolic and gene regulatory networksmetabolic engineeringmicrobial growthresource allocationsystems biotechnologyCivil Engineering, Environmental EngineeringJournal Article10.15480/882.813610.3389/fmolb.2022.80621310.15480/882.8136Journal Article