Checa Esteban, SaraSaraCheca EstebanByrne, Damien P.Damien P.ByrnePrendergast, Patrick J.Patrick J.Prendergast2024-07-082024-07-082012-12-10Advanced Structured Materials 1 (1): 423-435 (2012)9783642052408https://hdl.handle.net/11420/48243Computer simulation is a cornerstone of engineering design of high performance mechanical engineering equipment. However computer simulation is not so much used in the design of medical devices. The reasons for this are multifactorial and have their origin in the scepticism that biologists (and therefore clinicians) have regarding the plausibility of actually including all relevant factors in a computational model. In this work we have set out to model the response of tissues to changes in their mechanical environment, which could be caused by the presence of an implant or by damage of the tissue. We have used a lattice modelling approach, where the domain under analysis is discretized using both a finite element grid to compute biophysical stimuli and a 'lattice' to model cell activities. We applied the approach to two problems: (i) healing after bone fracture, and (ii) tissue regeneration inside a scaffold implanted into the body. © Springer-Verlag Berlin Heidelberg 2010.en1869-844120121423435SpringerTechnology::610: Medicine, HealthJournal ArticleJournal Article