Bletsos, GeorgiosGeorgiosBletsosKühl, NiklasNiklasKühlRung, ThomasThomasRung2021-04-082021-04-082021-07-02Engineering applications of computational fluid mechanics 15 (1): 1095-1112 (2021)http://hdl.handle.net/11420/9241This paper reports on the derivation and implementation of a shape optimization procedure for the minimization of hemolysis induction in biomedical devices. Hemolysis is a blood damaging phenomenon that may occur in mechanical blood-processing applications where large velocity gradients are found. An increased level of damaged blood can lead to deterioration of the immune system and quality of life. It is, thus, important to minimize flow-induced hemolysis by improving the design of next-generation biomedical machinery. Emphasis is given to the formulation of a continuous adjoint complement to a power-law hemolysis prediction model dedicated to efficiently identifying the shape sensitivity to hemolysis. The computational approach is verified against the analytical solutions of a benchmark problem and computed sensitivity derivatives are validated by a finite differences study on a generic 2D stenosed geometry. The application included addresses a 3D ducted geometry which features typical characteristics of biomedical devices. An optimized shape, leading to a potential improvement in hemolysis induction up to 22%, is identified. It is shown, that the improvement persists for different, literature-reported hemolysis-evaluation parameters.en1997-003X2021110951095CSE Dept., the H.K. PolyUhttps://creativecommons.org/licenses/by/4.0/Computational fluid dynamics(CFD)adjoint-based shape optimizationbiomedical designhemolysis minimizationPhysikJournal Article10.15480/882.365910.1080/19942060.2021.194353210.15480/882.36592101.10715v1Journal Article