Mattes, Daniela S.Daniela S.MattesStreit, BettinaBettinaStreitBhandari, Dhaka R.Dhaka R.BhandariGreifenstein, JulianeJulianeGreifensteinFoertsch, Tobias C.Tobias C.FoertschMünch, Stephan W.Stephan W.Münchv. Bojničić-Kninski, ClemensClemensv. Bojničić-KninskiRidder, BarbaraBarbaraRidderNesterov-Mueller, AlexanderAlexanderNesterov-MuellerSpengler, BernhardBernhardSpenglerSchepers, UteUteSchepersBräse, StefanStefanBräseLoeffler, Felix F.Felix F.LoefflerBreitling, FrankFrankBreitling2026-02-162026-02-162019-03-01Macromolecular Rapid Communications 40 (6): 1800533 (2019)https://hdl.handle.net/11420/61581Here, the combinatorial synthesis of molecule arrays via a laser-assisted process is reported. Laser-transferred polymer nanolayers with embedded monomers, activators, or bases can be reliably stacked on top of each other, spot-by-spot, to synthesize molecule arrays. These various chemicals in the nanometer-thin layers are mixed by heat or solvent vapor, inducing coupling reactions. As an example, peptoid arrays with a density of 10 000 spots per cm ² with the sub-monomer or monomer method are generated. Moreover, successful reactions spot-by-spot are verified by laser-transferring MALDI-matrix (Matrix-assisted laser desorption/ionization) followed by MALDI mass spectrometry imaging.en1521-392720196high-throughput screeninglaser-induced forward transferMALDI-MS imagingmolecule arrayssubmonomer methodTechnology::600: TechnologyJournal Article10.1002/marc.201800533Journal Article