Martínez Cristancho, Carlos AndrésCarlos AndrésMartínez CristanchoPeper, StephanieStephaniePeperJohannsen, MonikaMonikaJohannsen2020-02-042020-02-042012Journal of Supercritical Fluids (66): 129-136 (2012)http://hdl.handle.net/11420/4720Supercritical fluid-simulated moving bed (SF-SMB) chromatography is an attractive technology thanks to the outstanding performance of continuous countercurrent adsorption processes in combination with the tunability of eluent strength of supercritical CO 2. This work focuses on the process development steps of simulated moving bed chromatography for the separation of ethyl linoleate and ethyl oleate on silica gel using supercritical carbon dioxide under linear conditions. Adsorption isotherms of the components of interest were determined at analytical scale and applied together with the equilibrium theory for the design of a two-step SF-SMB process for the separation of the fatty acid ethyl esters. Results of the experimental validation of the continuous chromatographic separation of ethyl linoleate and ethyl oleate are shown and discussed in detail.en0896-84462012129136Elsevier ScienceFatty acid ethyl estersLinear adsorption coefficientSimulated moving bed chromatography (SMB)Supercritical fluid chromatography (SFC)PhysikJournal Article10.1016/j.supflu.2012.02.015Journal Article