Breslin, ThomasThomasBreslinPaino, JasonJasonPainoWegner, MarieMarieWegnerEngels, EletteEletteEngelsFiedler, StefanStefanFiedlerForrester, HelenHelenForresterRennau, HannesHannesRennauBustillo, John PaulJohn PaulBustilloCameron, MatthewMatthewCameronHäusermann, DanielDanielHäusermannHall, ChristopherChristopherHallKrause, DieterDieterKrauseHildebrandt, GuidoGuidoHildebrandtLerch, MichaelMichaelLerchSchültke, ElisabethElisabethSchültke2023-07-252023-07-252023-05-31Biomimetics 8 (2): 230 (2023)https://hdl.handle.net/11420/42254The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.en2313-767320232MDPIhttps://creativecommons.org/licenses/by/4.0/anthropomorphic phantomCT scandosimetryexperimental radiotherapymicrobeam radiotherapy (MRT)therapy planningtissue-equivalent materialsLife Sciences, BiologyMedicine, HealthJournal Article10.15480/882.797710.3390/biomimetics802023010.15480/882.7977Journal Article