Grube, SarahSarahGrubeGrünhagen, SörenSörenGrünhagenSchlaefer, AlexanderAlexanderSchlaeferMeyling, MichaelMichaelMeylingLatus, SarahSarahLatus2026-01-232026-01-232026-01-20Current Directions in Biomedical Engineering 11 (2): 68-71 (2025)https://hdl.handle.net/11420/61073Estimating the elasticity of soft tissue can provide useful information for various diagnostic applications. Ultrasound shear wave elastography offers a non-invasive approach. However, its generalizability and standardization across different systems and processing pipelines remain limited. Considering the influence of image processing on ultrasound based diagnostics, recent literature has discussed the impact of different image processing steps on reliable and reproducible elasticity analysis. In this work, we investigate the need of ultrasound pre-processing steps for deep learning-based ultrasound shear wave elastography. We evaluate the performance of a 3D convolutional neural network in predicting shear wave velocities from spatio-temporal ultrasound images, studying different degrees of pre-processing on the input images, ranging from fully beamformed and filtered ultrasound images to raw radiofrequency data. We compare the predictions from our deep learning approach to a conventional timeof- flight method across four gelatin phantoms with different elasticity levels. Our results demonstrate statistically significant differences in the predicted shear wave velocity among all elasticity groups, regardless of the degree of pre-processing. Although pre-processing slightly improves performance metrics, our results show that the deep learning approach can reliably differentiate between elasticity groups using raw, unprocessed radiofrequency data. These results show that deep learning-based approaches could reduce the need and the bias of traditional ultrasound pre-processing steps in ultrasound shear wave elastography, enabling faster and more reliable clinical elasticity assessments.en2364-5504202626871Walter de Gruyter GmbHhttps://creativecommons.org/licenses/by/4.0/Technology::616: Diseases::616.0: Pathology, Deseaeses, Treatment::616.07: PathologyTechnology::621: Applied Physics::621.3: Electrical Engineering, Electronic EngineeringComputer Science, Information and General Works::006: Special computer methods::006.3: Artificial Intelligence::006.31: Machine LearningJournal Articlehttps://doi.org/10.15480/882.1656710.1515/cdbme-2025-031810.15480/882.16567Journal Article