Lu, YongtaoYongtaoLu2021-06-292021-06-292015-07-03Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 3 (3): 172-176 (2015-07-03)http://hdl.handle.net/11420/9815Quantitative computed tomography-based finite element (FE) modelling technique is a promising tool for the prediction of bone fracture risk in clinic. However, FE models created from CT image datasets acquired at different scan conditions may yield comparably different results. The aim of this study was to investigate the influence of specimen scan condition on the FE models. Eight thoracolumbar vertebrae (T12) were scanned prior to autopsy (in situ). Afterwards, the segments (T10–L1) were dissected and scanned again under in vitro condition. Both scans were performed with high-resolution scan protocols, and the images were reconstructed with a voxel size of 0.18 mm × 0.18 mm × 0.3 mm. FE models with the cuboid volume of interest from the vertebral cancellous part were created. Inhomogeneous nonlinear bone properties were defined and the axial compression was simulated. The apparent bone mineral density, the modulus and yield strength showed significant differences in the two scan condition groups. In conclusion, the specimen scan condition may have to be considered when transferring the in vitro research knowledge into in vivo clinical applications.en2168-116320153172176finite element modelin situin vitroQCT imagescan conditionvertebraJournal Article10.1080/21681163.2014.947385Other