Horatz, KilianKilianHoratzDitte, KristinaKristinaDittePrenveille, ThomasThomasPrenveilleZhang, Ke-NanKe-NanZhangJehnichen, DieterDieterJehnichenKiriy, AntonAntonKiriyVoit, BrigitteBrigitteVoitLissel, FranziskaFranziskaLissel2023-04-112023-04-112019-06-18ChemPlusChem 84 (9): 1338-1345 (2019-09-01)http://hdl.handle.net/11420/15152Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.en2192-65062019913381345Wiley-VCHamorphous morphologyconjugated polymerslow-molecular-weight analytesMALDI mass spectrometrymatricesChemieJournal Article10.1002/cplu.20190020331944045Journal Article