Dora, JohannesJohannesDoraMöddel, MartinMartinMöddelFlenner, SiljaSiljaFlennerSchroer, Christian G.Christian G.SchroerKnopp, TobiasTobiasKnoppHagemann, JohannesJohannesHagemann2024-04-192024-04-192024-03-25Optics Express 32 (7): 10801-10828 (2024)https://hdl.handle.net/11420/47174The phase problem is a well known ill-posed reconstruction problem of coherent lens-less microscopic imaging, where only the squared magnitude of a complex wavefront is measured by a detector while the phase information of the wave field is lost. To retrieve the lost information, common algorithms rely either on multiple data acquisitions under varying measurement conditions or on the application of strong constraints such as a spatial support. In X-ray near-field holography, however, these methods are rendered impractical in the setting of time sensitive in situ and operando measurements. In this paper, we will forego the spatial support constraint and propose a projected gradient descent (PGD) based reconstruction scheme in combination with proper preprocessing and regularization that significantly reduces artifacts for refractive reconstructions from only a single acquired hologram without a spatial support constraint. We demonstrate the feasibility and robustness of our approach on different data sets obtained at the nano imaging endstation of P05 at PETRA III (DESY, Hamburg) operated by Helmholtz-Zentrum Hereon.en1094-4087202471080110828Opticahttps://creativecommons.org/licenses/by/4.0/Medicine, HealthJournal Article10.15480/882.948310.1364/OE.51464110.15480/882.9483Journal Article