Mohn, FabianFabianMohnSzwargulski, PatrykPatrykSzwargulskiKaul, Michael GerhardMichael GerhardKaulGräser, MatthiasMatthiasGräserMummert, TobiasTobiasMummertKrishnan, Kannan M.Kannan M.KrishnanKnopp, TobiasTobiasKnoppAdam, GerhardGerhardAdamSalamon, JohannesJohannesSalamonRiedel, ChristophChristophRiedel2024-04-242024-04-242024-03-10International Journal on Magnetic Particle Imaging 10 (1, suppl. 1): 2403031 (2024)https://hdl.handle.net/11420/47247Gastrointestinal (GI) bleeding is a potentially life-threatening condition that is typically diagnosed using radiation-based imaging modalities such as computed tomography (CT) or catheter-based angiography. Magnetic Particle Imaging (MPI) could provide non-invasive, real-time volumetric imaging without ionizing radiation in future human-sized scanners that covers the entire GI tract. We have developed a human-sized (3D printed) phantom that represents both the bowel lumen and the vascular compartment of the bowel wall. One version has a perforation between the two compartments and a control phantom does not. For single contrast MPI, we evaluate the fluid exchange between the two lumen by observing an administered blood pool tracer. For multi-contrast MPI, the intestinal lumen was filled with an intestinal tracer, which represents an orally administered tracer, to allow co-registration of both tracers at the same location. Both single-and multi-contrast MPI are feasible to visualize GI bleeding and MPI may prove to be a useful tool for radiation-free detection of bleeding throughout the GI tract.en2365-903320241, suppl. 1Infinite Science Publishinghttps://creativecommons.org/licenses/by/4.0/Medicine, HealthJournal Article10.15480/882.951910.18416/ijmpi.2024.240303110.15480/882.9519Journal Article