Liu, YuxinYuxinLiuZhu, XingjunXingjunZhuWei, ZhengZhengWeiWu, KefanKefanWuZhang, JunfangJunfangZhangMutti, Francesco G.Francesco G.MuttiZhang, HongHongZhangLoeffler, Felix F.Felix F.LoefflerZhou, JingJingZhou2025-12-042025-12-042023-07-24Angewandte Chemie International Edition 62 (30): e202303570 (2023)https://hdl.handle.net/11420/59384Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo-induced apoptosis, caused by individual intratumoral differences. Here, a multi-channel lanthanide nanocomposite was used to achieve tailored synergistic treatment of multiple subcutaneous orthotopic tumors under non-uniform whole-body infrared irradiation prescription. The nanocomposite reduces intratumoral glutathione by simultaneously activating the fluorescence and photothermal channels. The fluorescence provides individual information on different tumors, allowing customized prescriptions to be made. This enables optimal induction of hyperthermia and dosage of chemo drugs, to ensure treatment efficacy, while avoiding overtherapy. With an accessional therapeutic laser system, customized synergistic treatment of subcutaneous orthotopic cancer cases with multiple tumors is possible with both high efficacy and minimized side effects.en1521-3773202330Drug ReleaseFluorescent ProbesLanthanide-Doped NanoparticlesSynergistic TherapyTemperature SensingTechnology::600: TechnologyJournal Article10.1002/anie.202303570Journal Article