Thieben, FlorianFlorianThiebenMohn, FabianFabianMohnFörger, FynnFynnFörgerHackelberg, NiklasNiklasHackelbergScheel, Jan-PhilippJan-PhilippScheelGräser, MatthiasMatthiasGräserKnopp, TobiasTobiasKnopp2023-04-202023-04-202023-03-19International Journal on Magnetic Particle Imaging 9 (1): 2303045 (2023)http://hdl.handle.net/11420/15210Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane that is shifted with low frequency by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 µgFe with respect to the iron mass in a sensitivity study.en2365-903320231Infinite Science Publishinghttps://creativecommons.org/licenses/by/4.0/TechnikIngenieurwissenschaftenJournal Article10.15480/882.508510.18416/IJMPI.2023.230304510.15480/882.5085Journal Article