Sharma, Pratyush NidhiPratyush NidhiSharmaSarstedt, MarkoMarkoSarstedtRingle, Christian M.Christian M.RingleCheah, Jun HwaJun HwaCheahHerfurth, AnneAnneHerfurthHair, Joseph F.Joseph F.Hair2024-05-292024-05-292024-10-01International Journal of Information Management 78: 102805 (2024)https://hdl.handle.net/11420/47636The ongoing scientific discourse surrounding the replication crisis in behavioral research, including management information systems (MIS) research, underscores the importance of innovative and rigorous approaches to theory development and validation. This article proposes the EP-mixed framework, which addresses the necessity of an ontological distinction between explanation and prediction in MIS theories, along with the epistemological challenges associated with conflating exploratory and confirmatory research during the design of robust, replicable theories. EP-mixed refers to theories that explain and predict (i.e., EP theories) developed using a mixed mode that combines the strengths of both exploratory and confirmatory research. The EP-mixed framework guides researchers in selecting appropriate analytical approaches based on their research goals and the type of theory being developed. While it can be applied in conjunction with a broad spectrum of statistical methods to enhance the robustness and replicability of MIS theories, we elaborate on the predictive analytic tools available in partial least squares structural equation modeling (PLS-SEM) as an exemplar for operationalizing the framework.en1873-47072024ElsevierConfirmationEP-mixedExplanationExplorationOpen SciencePLS-SEMPredictionReplicabilitySocial Sciences::330: EconomicsJournal Article10.1016/j.ijinfomgt.2024.102805Journal Article