Mitrev, Yavor N.Yavor N.MitrevMehandzhiyski, Aleksander Y.Aleksander Y.MehandzhiyskiBatovska, Daniela I.Daniela I.BatovskaLiese, AndreasAndreasLieseGalunsky, BorisBorisGalunsky2019-08-012019-08-012016Journal of the Serbian Chemical Society 11 (81): 1231-1237 (2016)http://hdl.handle.net/11420/3043An E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (EC 3.5.1.14) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (EC 3.5.1.81) also catalyzed the reaction between acetophenone and p-nitrobenzaldehyde. Such a "green" approach to the synthesis of chalcones is of great interest because of the important applications of chalcones as formula ingredients in the pharmaceutical, food and cosmetic industries.en1820-742120161112311237Soc.ChemieIngenieurwissenschaftenJournal Article10.2298/JSC160422069MOther