Checa Esteban, SaraSaraCheca EstebanPrendergast, Patrick J.Patrick J.Prendergast2024-07-092024-07-092008-12-014th European Conference of the International Federation for Medical and Biological Engineering : ECIFMBE 2008 23–27 November 2008 Antwerp, Belgium / edited by R. Magjarevic, J. H. Nagel, Jos Vander Sloten, Pascal Verdonck, Marc Nyssen, Jens Haueisen. - Berlin, Heidelberg : Springer Berlin Heidelberg, 2009.- S. 2195-21999783540892076https://hdl.handle.net/11420/48291Angiogenesis, the formation of new capillaries from pre-existing vessels, plays a critical role during bone regeneration and repair. In addition to an appropriate mechanical environment, sufficient supply of oxygen and nutrients is critical for bone formation. Mechano-biological models have been previously used to predict the time course of the differentiation process with the mechanical environment as the only regulator of cell activity. Here we propose a mechano-biological model for tissue differentiation where cell activity is regulated by both the local mechanical environment and the local vascularity. Results show a significant effect of the morphology of the new capillary network on bone formation and heterogeneous distributions of cells similar to those seen in histological studies. © 2009 Springer Berlin Heidelberg.enAngiogenesisBlood vessel formationCapillary networkMechanobiologyMechano-regulationTissue differentiationTechnology::610: Medicine, HealthConference Paper10.1007/978-3-540-89208-3_525Conference Paper