Zimmermann, KristinaKristinaZimmermannFieg, GeorgGeorgFieg2019-04-262019-04-262018-07Computer Aided Chemical Engineering 44: 763-768 (2018)978-0-444-64241-7http://hdl.handle.net/11420/2527The simulation-based multi-objective structural and parameter optimization of continuous chemical production processes is a complex task. To provide a universally applicable optimization tool, the Advanced Process Optimizer was developed and intensively tested in cooperation with different industrial partners over several years. The superstructure can be directly built in a commercial flowsheet simulator. The resulting Generalized Disjunctive Programming formulation of the optimization problem was handled through a combination of newly developed and adapted methods. In order to validate the efficiency of the developed optimization tool the example of a dimethyl ether production process was chosen. The optimization results are compared to a reference solution achieved by conventional approaches and show a significant reduction of both the investment and operating costs.enTechnology::600: TechnologyConference Paper10.1016/B978-0-444-64241-7.50122-1Conference Paper