Kaemmerer, HenningHenningKaemmererBrunner, GerdGerdBrunnerJohannsen, MonikaMonikaJohannsen2020-02-062020-02-062007Journal of Supercritical Fluids 2 (43): 204-213 (2007)http://hdl.handle.net/11420/4770The objective of this work was to establish a solvent cycle with a possibility for modifier control in a preparative supercritical fluid chromatography simulated moving bed plant (SFC-SMB). Fourier transform infrared (FTIR) spectroscopy and flame ionization detection (FID) have been investigated for measuring alcohol concentrations in supercritical carbon dioxide. The integration of these in-line techniques into a modifier control schema allowed the operation of a closed loop SFC-SMB cycle. The applicability of the developed control concept for usage of 2-propanol in supercritical carbon dioxide has been verified by an experimental test series involving an eight column SFC-SMB plant. Different process variations have been compared in terms of energy and solvent consumption. Hereby, savings of almost all CO2 and 76% modifier could be achieved.en0896-84462007204213ControlFourier transform infrared spectroscopy (FTIR)ModifierSimulated moving bed (SMB)Solvent cycleSupercritical fluid chromatography (SFC)IngenieurwissenschaftenJournal Article10.1016/j.supflu.2007.02.011Other