Innovation in any business comes with risk. This study aimed to explore the role of managerial risk-taking and integrated risk management (IRM) on innovation. To verify the hypotheses, a questionnaire was designed. Data were collected from 109 Insurance Managers from Iran Insurance Companies. PLS structural equation modeling was employed to test both measurement and structural model. The results demonstrate that integrated risk management and managers’ risktaking have a positive impact on innovation. This is the first study to explicitly and separately consider the effects of managerial risk-taking and integrated risk management (IRM) on innovation in the Insurance sector. Due to the lack of scales to analyze IRM, questionnaires which adopted from previous studies may not be the best scales to measure variables. This study focuses on Iran insurance industry, which limits its generalizability. Our findings highlight the need for managers in high risk-taking behavior to encourage employees to be more creative and develop organizational innovation. The authors discovered that firms should perform an effective IRM system that oversees many systematic risks through organization innovation process.