Multiskalige modellgestützte Untersuchungen der Formation von katalytisch aktiven Clustern und Agglomeraten großer Multienzymkomplexe

Motivation

Targeted formation of stable enzyme clusters and agglomerates is of highest interest for the construction of efficient and adjustable bioreaction cascades
Nowadays no suitable methodology available to predict formation and stability of clusters and agglomerates
Impact of process parameters – pH, temperature, mechanical stress – on cluster and aggregate formation and functionality yet hardly investigated

Objectives of this project:
Identify mechanisms and determinants responsible for building functional and efficient agglomerates.
Develop and validate solid model framework to describe and predict dynamic formation and reformation of multi-enzymatic complex clusters and agglomerates
Influence of process conditions on formation and catalytic efficiency

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