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Item type:Publication, Access status: without files , Evaluation of process integration for the intensification of a biotechnological process(2021-10); ; ; ; Process intensification is a well-known and established method to improve ecological and economic efficiency of large-scale chemical processes. Process intensification in form of integrating an in-situ product or intermediate removal can also improve processes. In this study the effects of integrating an intermediate separation in form of an extraction centrifuge and a product separation in form of a pre-purification into a multi-enzyme cascade as well as the potential for further process integration in form of a reactive extraction centrifuge are analyzed for a biotechnological process. In order to evaluate the application of process integration, different process configurations are compared regarding to the efficiency using a model-based approach. Although the highly integrated process leads to lower space-time yields in some cases, an operating window can be identified in which the space-time yield is significantly higher compared to a sequential process. In order to distinguish both cases and thus choose a suitable operating point simulative studies are required. Moreover, a potential for further integration can be identified for the reference process studied in this work.Publicationtype: Journal Article97 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Multi-enzyme cascade reaction in a miniplant two-phase-system: model validation and mathematical optimization(Wiley, 2021-01-11); ; ; ; Biotechnological application of multiple enzymes in different phases for target compounds synthesis poses a significant challenge for industrial process development. At the same time, a growing demand for natural flavors and fragrances opens up possibilities for novel biotechnological processes to replace current chemical synthesis routes, with additional advantages such as avoiding harsh reaction conditions and toxic chemicals, and less by-products in the system. Within complex biotechnological processes, the key for unfolding their industrial application potential in bioprocess engineering lies in their mathematical modeling. In this contribution, a multi-enzyme cascade reaction in a two-phase system implemented in a miniplant-scale reactor setup is mathematically modeled for the example of the flavoring agent cinnamyl cinnamate. Using our validated model and a mathematical optimization tool based on a genetic algorithm, optimization runs are performed to demonstrate the potential of computer-aided process development for complex biotechnological processes.Publicationtype: Journal ArticleScopus© Citations 11 157 338