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Item type:Publication, Access status: with files , Use of electrical impedance spectroscopy to distinguish cancer from normal tissues with a four electrode terminal setup(De Gruyter, 2020-11-26); ; ; Cancer and normal tissues are visually different from each other, especially so in more advanced cancer stages. More important, they are not only visually contrasting, but if an electric field is applied to both tissue types and the frequency is varied in a wide range, it will be seen that the two tissue types in general have a spectral response divergent from each other and this has to do with the characteristics of cancer tissues in contrast to normal ones. In this work, Electrical Impedance Spectroscopy is applied to try to distinguish cancer from healthy tissues by means of their impedance spectrum using a four-electrode-terminal setup. The use of the fourterminal- setup setup is important to circumvent the impact of electrode polarization at frequencies below 1 kHz.Publicationtype: Journal ArticleScopus© Citations 5 179 204 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Electrical Impedance Spectroscopy for Characterization of Prostate PC-3 and du 145 Cancer CellsThe impedance profile of the human PC-3 and DU 145 prostate cancer cells were recorded and compared using Electrical Impedance Spectroscopy. Cells were measured in a special chamber using a four terminal setup to avoid parasitic effects of electrode polarization in low frequencies. Our results show that the two cancer cell lines are readily distinguishable by their impedance spectrum. As PC-3 cells have been shown to be spontaneously metastatic in previous xenograft experiments while DU 145 cells were non-metastatic, Electrical Impedance Spectroscopy has the potential to be developed into a simple diagnostic tool to distinguish metastatic from non-metastatic cells.Publicationtype: Conference Paper331 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Bioimpedance spectroscopy for characterization of healthy and cancerous tissuesBioimpedance spectroscopy is a technique that can potentially be used to differentiate healthy from sick tissues based on the variation of electrical properties of biological material when submitted to frequency variable electric fields. In this paper, the technique was applied to measure the impedance of five different tissues of a healthy mice and two cancerous infected with the tumor lines UT-SCC-5 (tongue squamous cell carcinoma) and UM-SCC-10A (laryngeal squamous cell carcinoma). Results show that the different tissue types show a significant variation in their impedance values. More interestingly is that the two cancerous tumors have the highest conductivity values, or equivalently the lowest impedance values.Publicationtype: Conference Paper203 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Bioimpedance analysis of L929 and HaCaT cells in low frequency range(De Gruyter, 2018-09-01); ; ; In this work, Bioimpedance Spectroscopy (BIS) is used to study fuids and cell solutions. A new four-electrode-terminal (4T) chamber using 3D printing and stainless steel corrosion resistant V4A was designed to measure the impedance of live cell solutions at the frequency range 0.1Hz-1MHz. At f < 1kHz the double layer (DL) that builds at electrode's surface raises the impedance substantially preventing the observation of the real impedance of the cells. The new 4T design circumvents the DL, is more robust and cheap, and allows for the repeatability of the results. Experiments were performed in vitro with two cell lines, L929 (mouse fbroblasts) and HaCaT (human keratinocytes). Results show that it is possible to distinguish between the two cell types by means of its BIS measurements in the new setup. Also, a low-frequency dispersion (α-dispersion) was observed in HaCaT cells solution, but not in L929. Furthermore, a potentiostat circuit model was developed in LTSpice to simulate the hardware setup and two different circuit models were used to ft cell's data. © 2018 Viviane S. Teixeira et al.Publicationtype: Journal ArticleScopus© Citations 6 298 433